MHS FRS: Institute of Inflammation and Repair: 18 March 2015
Wednesday, March 18, 2015 from 12:30 PM to 2:00 PM (GMT)
San Francisco, California
London, United Kingdom
12.30-2pm (lunch 12.30-1.00pm; presentations 1.00-2.00pm)
Room 1.008, Roscoe building (lunch in Foyer, Roscoe building)
Hosted by Institute of Inflammation and Repair (IIR) with Manchester Collaborative Centre for Inflammation Research (MCCIR)
Senior presenter: Professor Andrew MacDonald (MCCIR), “Inflammation at the interface: dendritic cell co-ordination of Type 2 immunity”
Professor Andrew MacDonald’s research investigates how pathogen interaction with the innate immune system influences the development of adaptive immunity and inflammation. His particular interest is Type 2 inflammation, which is responsible for widespread suffering in allergy, as well as being a hallmark of infection with parasitic worms (helminths). His laboratory’s work addresses some outstanding fundamental questions about the role of a specialised type of immune cell – the dendritic cell (DC) – in orchestration of Type 2 inflammation. DCs are centrally involved in initiation of immune responses in most settings, but the precise mechanisms by which they direct Type 2 inflammation are currently not known.
Junior presenter: Dr Margherita Bertuzzi, Institute of Inflammation and Repair, “Mould pathogenesis in the mammalian lung”
Dr Margherita Bertuzzi is a postdoctoral research fellow of the Manchester Fungal Infection Group. Her previous and current research focuses extensively on fungal pathogenesis, with particular emphasis on the filamentous fungus Aspergillus fumigatus and the mechanisms by which this major fungal pathogen senses and adapts to the mammalian host niche. A central feature of invasive lung diseases caused by A. fumigatus is the penetrative growth of fungal hyphae across the respiratory epithelium. However, the molecular basis of the host-pathogen interaction at this interface remains poorly characterised. By using a novel, non-invasive A. fumigatus mutant lacking a pH-responsive transcription factor, Margherita will present a model of host-mediated damage in which two major, and sequentially acting, processes impact epithelial integrity in vitro and tissue invasion.
Please note that places are limited. Registration: https://mhsfrs18mar2015.eventbrite.co.uk
Who is it for?
The monthly Faculty Research Series events are open to all staff and students from across the Faculty of Medical and Human Sciences and the University, offering an opportunity to celebrate research achievement and stimulate scientific interaction. Each month one host School or Institute from the Faculty will pair with a different School or Institute to highlight and showcase similar topics from different perspectives. The 2014 series is led by Professor David Eisner and administered from the Faculty Research Office.
Held on Wednesday lunchtimes, each meeting lasts an hour, including two 20 minute presentations – one from a senior and one from a more junior member of Faculty staff. Each presentation will be followed by a short discussion. A buffet lunch will be available from 12.30. Presentations begin at 1pm.