Through two days of talks, poster sessions, flash presentations and networking, the inaugural UK Proteostasis Conference will showcase diverse cutting-edge proteostasis research and address fundamental questions in the field, including how to expedite applications in pharmaceuticals, biotechnology, and agritech.

This conference will also launch the Proteostasis UK Network, which will unite the proteostasis community in the UK across the fields of protein folding, quality control, aggregation, degradation and beyond, to tackle challenges in fundamental biology and novel therapeutics through collaborations and sharing of resources, expertise and trainees.

Registration Deadline: 29th April 2024

Conference Speakers

We are delighted to be scheduling talks from academic and commercial research leaders in the proteostasis field, in addition to inviting flash talks to highlight a broad range of research from academic teams, and a panel discussion with pharmceutical leads.

Please find details of talks below, further details including a preliminary Conference agenda is available on the UK Proteostasis Conference webpage.

Keynote Talk: The Proteostasis Network as a Biological Clock for Health, Aging and Disease

Professor Rick Morimoto

Director of the Rice Institute for Biomedical Research at Northwestern University and Royal Society Wolfson Visiting Fellow at the University of Cambridge

"Quality control of membrane proteins"

Professor Pedro Carvalho, Sir William Dunn School of Pathology, University of Oxford

"The challenges of predicting amyloidogenicity"

Professor Sheena Radford, Faculty of Biological Sciences, University of Leeds

"Diverse ubiquitin chain topologies orchestrate plant immune signalling"

Professor Steven Spoel, Institute of Molecular Plant Sciences, University of Edinburgh

"Discovery and development of NXP800: a clinical stage GCN2/ISR activator that inhibits HSF1 transcription for the treatment of ARID1A mutant ovarian cancer"

Professor Paul Workman, Signal Transduction & Molecular Pharmacology team, Institute of Cancer Research

"Deconvoluting cellular proteostasis strategies across proliferative states"

Dr Rahul Samant, Group Leader, Babraham Institute

"Induced control of protein degradation"

Dr Benedict Cross, Chief Technology Officer, PhoreMost

"Exploring lysosomal dysfunction in cellular senescence"

Dr Bernadette Carroll, Senior Research Fellow, University of Bristol

"Dysregulated proteostasis as a virulence mechanism of pathogenic bacteria, the case of the Mycobacterium ulcerans exotoxin mycolactone"

Professor Rachel Simmonds, Head of the Department of Microbial Sciences and Professor of Immunopathogensis, University of Surrey

"Increased fidelity of protein synthesis extends lifespan"

Dr Ivana Bjedov, Principal Research Fellow, Molecular Biology of Cancer Research Group, UCL Cancer Institute

"Protein phase transitions"

Professor Tuomas Knowles, Department of Chemistry, University of Cambridge

"How neuronal signalling connects perception with proteostasis and ageing"

Dr Rebecca Taylor, School of Biological Sciences, University of East Anglia

Panel Discussion : How can our knowledge of proteostasis be translated into therapeutic benefit?

Chair: Kathryn Chapman, Director, Science & Entrepreneurship at Babraham Research Campus

Panel:

Paul Thompson, Chief Scientific Officer, Mission Therapeutics
Fiona Menzies, Associate Vice President, Eli Lilly and Company
James Hunt, R&D Biologics Engineering, AstraZeneca
Wei-Li(William) Kuan, Head of Biology of the Alborada Drug Discovery Institute, University of Cambridge
Ralph Minter, Senior Vice President of Research, Alchemab Therapeutics

The UK Proteostasis Conference is kindly sponsored by:

UK Proteostasis Conference 2024