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25th Sackler Distinguished Lecture, speaker Dr KJ Patel

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William Harvey Lecture Theatre

School of Clinical Medicine

Cambridge Biomedical Campus

Cambridge

CB2 0SP

United Kingdom

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Dr Patel's talk is entitled ‘From gin and tonics to formalin pots – how simple aldehydes impact human health’. He is a brilliant communicator and this is a great opportunity to hear a speaker of international renown.

Dr KJ Patel trained in medicine in London but also has spent his research career at the MRC Laboratory of Molecular Biology, Cambridge. His work focuses on the molecular basis of inherited genomic instability and the role it plays in the biology of stem cells.

His research has led to new insights into how toxic molecules released from metabolism can damage the DNA of stem cells, particularly in those that produce blood. Studies carried out by his laboratory have uncovered how the body defends itself against these toxic metabolites through a dual protection mechanism that involves degradation of these metabolites and a specific form of DNA repair, the Fanconi anaemia DNA repair pathway. An important aspect of this work has also shown how the toxic by-product of alcohol metabolism, acetaldehyde, damages DNA and may contribute to diseases associated with ethanol exposure, such as fetal alcohol syndrome, bone marrow dysfunction and certain cancers. He is a Fellow of the Royal Society (FRS), a member of EMBO and a Fellow of the Academy of Medical Sciences UK (FMedSci).

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William Harvey Lecture Theatre

School of Clinical Medicine

Cambridge Biomedical Campus

Cambridge

CB2 0SP

United Kingdom

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