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'A Celtic curiosity–the evolving concept of oral Crohn’s disease' & 'Lookin...

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Lecture Theatre 1,

New Hunts House Guy’s Campus

London

SE1 1UL

United Kingdom

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This evening will consist of two lectures.

Professor Jeremy Sanderson: A
Celtic curiosity - the evolving concept of oral Crohn's disease

Abstract: For more than 20 years, we have run a specialist clinic at Guy's Hospital for people with orofacial granulomatosis (OFG) building up a unique cohort of individuals with this rare but debilitating condition.

Traditionally considered a variant of Crohn's disease, our work suggests that OFG is more commonly an entirely separate disease entity. One defining feature is a striking link with allergy. Furthermore, genetic studies show that mutations strongly linked to Crohn's are not linked with pure OFG.

Strangely, the prevalence of OFG appears remarkably higher in Celtic countries suggesting a strong environmental link. A trial of a cinnamon and benzoate free diet at GSTT showed clear benefit and this diet as become our preferred first line treatment. Immunohistochemical studies have demonstrated novel IgE expressing B cells in the oral mucosa but the target antigen for this is unknown and is clearly an important next question. Studies are currently underway to examine the oral (salivary) microbiome in OFG.

OFG is a miserable condition - lip swelling in young people is a cause of significant psychological morbidity. However, our work is steadily improving both our understanding of the condition and the outcomes on treatment.

Biography: Professor Jeremy Sanderson qualified in Medicine from the University of London in 1984 and undertook his postgraduate training in London and Melbourne. He undertook an MD researching the bacterial aetiology of Crohn's disease at St. George's and then joined Guy's Hospital in 1993 as Senior Registrar and then became one of the first joint Guys & St. Thomas' Hospitals appointees as Consultant Gastroenterologist in 1994.

Over the last 23 years, he has steadily built up one of the largest and renowned IBD units in the UK at GSTT specialising in the personalised treatment of patients with IBD. In collaboration with a number of scientists at KCL, he has built an extensive program of translational research investigating the aetiology and optimised treatment of IBD, including genetics, pharmacogenetics, microbiology, immunopathology and a specific interest in oral Crohn's disease.

He is currently Clinical Director for Gastrointestinal Medicine and Surgery at GSTT.


Professor Denise Syndercombe-Court: Looking for the evidence

Abstract: Dissatisfaction with an early career choice led to a search for something more meaningful and a passion for the value of evidence. Night school and then an NHS scholarship allowed me to study for my doctorate in tropical haematology. Research in cardiology and cardiothoracic surgery followed before I gained an academic position in haematology at Barts and The London where the research was concerned with the use of blood groups and DNA for identification. At Barts, I developed my teaching in critical analysis of the evidence base in medicine and editing a medical textbook, while my research was focussed on forensic genetics. In 2012 I moved to King’s. My research group has expanded and we collaborate with scientists across Europe in an ‘excellence network’. Here we are at the forefront of research to develop and validate new ethical ways to provide intelligence for the criminal justice system.

Biography: Professor Syndercombe Court has over twenty years’ experience in scientific research and as an expert witness. She is editor of ‘Medical Sciences’ which won the 2015 BMA medical book prize. Since moving to ‘King’s’ from ‘Barts’ she has focussed her teaching on forensic genetics where she also supervises those undertaking research for their doctorates. Her expertise relates to human identification through DNA and she leads a Ministry of Justice accredited laboratory as part of King’s Forensics. Denise represents the UK on the European DNA profiling group, is the International Society of Forensic Genetics DNA representative to the Forensic Regulator and has been appointed to the Home Office Biometrics and Ethics Group. Her group has been the UK partner with other European Forensic Institutes where her research, and that of her group, focusses on the use of massively parallel sequencing to provide information on geographic ancestry, age, forensic metagenomics and complex mixture analysis to assist criminal justice.

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Lecture Theatre 1,

New Hunts House Guy’s Campus

London

SE1 1UL

United Kingdom

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