Monday, 23 June

An Introduction to Group Sequential Designs Workshop

Hey there! Join us for a hands-on workshop where we'll dive into the world of Group Sequential Designs together. See you there!

By Chen Ji

Date and time

Mon, 23 Jun 2025 09:30 - 12:15 GMT+1

Location

Warwick Medical School

A1.51 WMS Coventry CV4 United Kingdom

Agenda

9:00 AM - 9:30 AM

Prior preparation: Recap of single stage analysis and GSD head start

Peter Kimani

• Maximum likelihood estimator. • Test statistic, p-value and critical value (boundary). • Fisher information. • GSD notation head start. • Installing necessary R packages.

9:30 AM - 9:45 AM

Introduction to the day

9:45 AM - 10:30 AM

Introduction and common group sequential boundaries

Nigel Stallard

• Principle, advantages/disadvantages, etc. • Multivariate structure • Some common boundaries e.g. (1) Pocock boundary, and (2) O’Brien and Fleming boundary • Alpha-spending and different alpha-spend...

10:30 AM - 11:00 AM

Practical session

Peter Kimani

Facilitators

• Practical session: Illustration of designing a trial using GSD - “analytical” calculation (R program) and using R package “rpact” or “gsDesign”. • Exercise using “rpact” or “gsDesign”. • To give St...

11:00 AM - 11:30 AM

Break

11:30 AM - 12:10 PM

Example(s) of real WCTU trials (mention extension and trial design/results and

Nick Parsons

Nigel Stallard

• START:REACTS (Mention spending function and GSD extension because of using early endpoint and software) • RECOVERY-RS (Mention binary data, spending function and maybe interruption and subsequent g...

12:10 PM - 12:15 PM

Other considerations and close

• Mention that point estimates and confidence intervals need to be adjusted, and methods exist. • Close.

About this event

Event lasts 2 hours 45 minutes

Welcome to the An Introduction to Group Sequential Designs Workshop! Join us in person at Warwick Medical School for an exciting event where you will learn about group sequential designs including implementation using statistical software. This workshop is perfect for anyone interested in clinical trials and statistical analysis. Get ready to dive into the world of group sequential designs and discover how they can improve the efficiency of clinical trials and how to design and analyse group sequential trials. Don't miss out on this fantastic opportunity to expand your knowledge and network with fellow researchers.

Organised by

Chen Ji