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Annual Burton Lecture 2017
Wed 22 March 2017, 16:00 – 19:00 GMT
The Department of Chemistry are delighted to invite you to Annual Burton Lecture which is being delivered by Professor Jason Chin, from the MRC Laboratory of Molecular Biology, Cambridge.
Time: 16.00 – 17.00
Venue: New Hunt’s House Lecture Theatre 2, New Hunt's House, Guy's Campus
A drinks reception will follow the lecture:
17.00 – 19.00 in the Gordon Museum, Hodgkin Building, Guy's Campus
Title: "Reprogramming the Genetic Code"
Abstract: The information for synthesizing the molecules that allow organisms to survive and replicate is encoded in genomic DNA. In the cell, DNA is copied to messenger RNA, and triplet codons (64) in the messenger RNA are decoded - in the process of translation - to synthesize polymers of the natural 20 amino acids. This process (DNA RNA protein) describes the central dogma of molecular biology and is conserved in terrestrial life. We are interested in rewriting the central dogma to create organisms that synthesize proteins containing unnatural amino acids and polymers composed of monomer building blocks beyond the 20 natural amino acids. I will discuss our invention and synthetic evolution of new 'orthogonal' translational components (including ribosomes and aminoacyl-tRNA synthetases) to address the major challenges in re-writing the central dogma of biology. I will discuss the application of the approaches we have developed for incorporating unnatural amino acids into proteins and investigating and synthetically controlling diverse biological processes, with a particular emphasis on understanding the role of post-translational modifications.
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