Microbes are growing increasingly resistant to antibiotics, creating a global public health issue of immediate concern. The UK's strategy for overcoming this growing threat depends on the discovery and development of new antibiotics. Natural products have historically proven to be one of the most fruitful sources of antibiotics, with over half of all current clinically used antibiotics being derived from, or inspired by, natural products. During this event researchers from the University of Bristol will outline a current major research project that seeks to identify new natural product based antimicrobials from microorganisms that live on the seabed of the Atlantic Ocean. This project is already yielding a rich diversity of novel antimicrobial agents that show promise for future use in public health.