Researchers from the CRUK City of London Centre partners (UCL, King’s Health Partners, Barts/QMUL and the Crick) are invited to the CRUK City of London Centre 2020 Symposium on Cancer Biotherapeutics.

Programme

08:30-09:00 - Registration

09:00-09:10 - Welcome - Professor Tariq Enver

09:10-10:40 - Session 1 - Cancer evolution and tumour heterogeneity

Chair: Professor Francesca Ciccarelli

09:10-09:30 - Targeting Wnt signalling in colorectal cancer - Dr Vivian Li

09:30-09:50 - Post-translationally spliced epitopes of cancer cells - Dr Michele Mishto

09:50-10:10 - Probing the evolution heterogeneity in follicular lymphoma - Dr Giuseppe Palladino

10:10-10:40 - CoL Centre Student talks

Elucidating functional and non-functional genomic heterogeneity in lung cancer - James Black

Understanding exosome-mediated fibrosis to develop new therapies for PDAC - Sarah Duncan

Deciphering new molecular mechanisms driving poor risk Acute Myeloid Leukaemia - Jiexin Zheng

The role of MSCs derived inflammation in the pathogenesis of Myeloproliferative Neoplasms (MPN) and leukaemic transformation - Alessandra Ferrellli

Clonal evolution and immune evasion in primary colorectal cancer (CRC) and metastases - Vinaya Srirangam Nadhamuni

10:40-11:00 - Tea break

11:00-12:20 - Session 2 - Cross-disciplinary approaches enhancing biotherapeutics

Chair: Professor Kairbaan Hodivala-Dilke

11:00-11:20 - Molecular imaging in cancer – new radiotracers for treatment decision-making - Professor Philip Blower

11:20-11:40 - Mechanisms of tumour heterogeneity - Dr Axel Behrens

11:40-11:50 - CoL Centre Development fund

Connecting Single-Cell Ligands, Receptors, and Signals in Tumour Microenvironment Organoids - Dr Chris Tape

11:50-12:00 - CoL Centre Student talks

No more shots in the dark: tracking and quantifying CAR T-cells in solid tumours - Eva Bugallo Blanco

Investigating ADI-PEG20 metabolic therapy to target improved anti-cancer immune responses from CART - Michael Austin

12:00-12:20 - Combining Imaging and Mathematical Modelling to Reconstruct Virtual Tumours - Professor Rebecca Shipley

12:20-12:40 - Radnet

Cancer Research UK RadNet City of London Radiation Research Unit - Professor Gary Royle and Dr Erik Sahai

12:40-13:40 - Lunch

13:40-15:00 - Session 3 - Developing Biological Therapies

Chair: Dr Erik Sahai

13:40-14:00 - Title TBC - Professor Sergio Quezada

14:00-14:20 - Heme oxygenase-1 expressing macrophages in cancer: the wrong place at the wrong time - Dr James Arnold

14:20-14:40 - Targeting L-arginine as a novel cancer therapy - Professor Peter Szlosarek

14:40-14:50 - CoL Centre Development fund

Deep Learning of High Dimensional Genetic, Immune and Clinical Parameters to Predict Patient Response to Immune Checkpoint Blockade - Professor Francesca Ciccarelli

14:50-15:00 - CoL Centre Student talks

Investigation of strategies to avoid off-target toxicity while enhancing CAR T cell function in solid cancers - Charles Agbuduwe

15:00-15:30 - Tea break

15:30-16:40 - Session 4 - Paediatrics Cross-cutting Theme

Chairs: Professors Pamela Kearns and Josef Vormoor

15:30-15:50 - Epigenetic deregulation in malignant brain tumours - Professor Silvia Marino

15:50-16:10 - Senescence in Cancer: Protumourigenic Activities and Novel Therapies - Professor JP Martinez-Barbera

16:10-16:30 - Title TBC - Dr Sara Ghorashian

16:30-16:40 - CoL Centre Student talks

Understanding the role of senescence in paediatric high-grade glioma - Ashley Vardon

16:40-17:00 Closing remarks - Professor Anton Berns

17:00-19:00 Drinks Reception