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Department of Chemistry - Burton Lecture

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B.5 Auditorium

Franklin-Wilkins Building

Stamford Street

London

SE1 9NH

United Kingdom

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The King's College London Department of Chemistry proudly present the Annual Burton Lecture.

Professor Harold Burton was the first Head of the Department of Chemistry from 1947 until his death in 1966. The Harold Burton fund was established to be applied for the promotion of Chemistry in the College, which included an annual lecture. The Burton Lectures began in the 1970’s and many distinguished academics have participated over the years. In conjunction with the Department’s recent rejuvenation, the Burton Lectures were reintroduced in 2016.

This year's speaker is Professor Sabine L Flitsch from the University of Manchester.

Title:

'Design and implementation of de novo biosynthetic cascades'

Abstract:

The combination of sequential biocatalytic reactions in non-natural synthetic cascades is a rapidly developing field and leads to the generation of complex valuable chemicals from simple precursors. As the toolbox of available biocatalysts continues to expand, so do the options for biocatalytic retrosynthesis of a target molecule, leading to new routes employing enzymatic transformations. The implementation of such cascade reactions requires careful consideration, particularly with respect to whether the pathway is constructed in vitro or in vivo. This lecture will showcase three successful de novo cascades and discuss the relative merits of in vitro, in vivo or hybrid approaches to building biocatalytic cascades and analytical challenges. Biocatalysts were obtained either directly from genomic libraries, or by re-design of enzyme activity to suit requires substrate specificity and selectivity.

Recent references: ACS Catalysis 2017, 7, 710; ACS Catalysis 2017, 7, 2920; JACS 2017, 139, 1408; ACIE 2017, 56, 1; ACIE 2017, 56, 14498; Nature Comm 2017, 8, 973; ACIE 2016, 55, 1511; Nature Chemistry 2014, 6, 65; JACS 2012, 134, 4521.


The lecture will be followed by a drinks reception in The Conservatory of the Franklin-Wilkins Building, from 17.00.


If you have any special requirements please email: chemistry@kcl.ac.uk

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B.5 Auditorium

Franklin-Wilkins Building

Stamford Street

London

SE1 9NH

United Kingdom

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