Actions and Detail Panel
Edinburgh Research Interest Group Meeting
Sat 22 April 2017, 10:30 – 13:30 BST
Dr Esther Sammler from the University of Dundee has kindly agreed to give a talk entitled:
Genes, genetics and signalling pathways in Parkinson's: from bench to bedside.
There are many proteins and pathways that play a role in the cascade of events that eventually result in a person developing Parkinson’s disease. The development of new treatments and ultimately a cure of Parkinson’s disease will depend on a much deeper understanding of these events. Changes in the LRRK2 gene are the greatest known genetic contributor to Parkinson’s disease, accounting for 1-2 % of all cases and even more so (up to 40%) in people with certain ethnic backgrounds. Professor Alessi’s team together with international collaborators has recently identified a new link between LRRK2 and members of the Rab protein family, other crucial players in the Parkinson’s field. I am focusing on translating these new discoveries from ‘bench to bedside’ by establishing a test by which I can explore this new signalling pathway in human blood samples. Such a test would provide the Parkinson’s community with a tool to measure the impact of novel drugs in testing – in particular LRRK2 inhibitors -, point to potential new drug targets and allow monitoring LRRK2 pathway activity in patients with genetic, but also sporadic Parkinson’s.
What are my transport/parking options for getting to and from the event?
There is free parking available at SCRM on Saturday.Turn right off Little France Drive and wait for the barrier to rise. If there are no spaces outside the main entrance, there are plenty morre behind the SCRM building, reached by turning left immediately after the barrier and left again.
The SCRM building is just a short walk from the main bus hub at the Edinburgh Royal Infirmary. Lothian buses nos. 7, 8, 18, 21, 24, 33, 38 ,49 all serve the site.