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Exploring the ‘ologies’ of Crohn’s disease: microbiology, immunology and st...

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Perrin Lecture Theatre

Blizard Institute, Queen Mary University of London

4 Newark Street

London

E1 2AT

United Kingdom

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Exploring the ‘ologies’ of Crohn’s disease: microbiology, immunology and stem-cell biology

The Inaugural lecture of Professor James Lindsay will take place on 13 March 2018. Please find an introduction and biog below.

Crohn’s disease manifests as chronic intestinal inflammation leading to a high burden of symptoms for patients. Although the exact aetiology is not defined, it likely involves uncontrolled immune responses to aspects of the gut microbiota in genetically susceptible individuals, often triggered by environmental exposures. Conventional therapies suppress the immune system but are not effective in all patients and are associated with side effects. Although attractive to patients, interventions to alter the intestinal microbiota have not shown clinical benefit. Re-setting the immune system using stem cell transplantation is emerging as a potential therapy but requires further research. In this lecture I will discuss my translational research and clinical trials program that explores the immunology, microbiology and stem-cell biology of Crohn’s disease.

Please note there will be a drinks reception in the foyer after the lecture.

Brief Biography

James Lindsay is the Professor of Inflammatory Bowel Disease at Barts and the London School of Medicine and Dentistry, Queen Mary University of London and a Consultant Gastroenterologist at Barts Health NHS Trust. Along with a full multidisciplinary team he leads the adolescent and adult IBD service at The Royal London Hospital. He is the Education Officer and a member of the Governing Board of the European Crohn’s and Colitis Organisation (ECCO) and has led development of National and International guidelines on the management of IBD.

He is Chief Investigator for a series of investigator-led and pharmaceutical clinical trials in IBD. He leads the NIHR funded ASTIClite trial which will assess the efficacy, safety and mechanism of action of low intensity autologous stem cell transplantation in patients with refractory Crohn’s disease. His translational research programme investigates manipulation of the microbiota, intestinal immune system and epigenetic control of gene expression to modify intestinal inflammation and fibrosis in Crohn’s disease. He has published over 90 papers in journals including The Lancet, JAMA, Gastroenterology and Gut and has generated at least £5 million in research income from research councils and charities.

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Perrin Lecture Theatre

Blizard Institute, Queen Mary University of London

4 Newark Street

London

E1 2AT

United Kingdom

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