Fighting immortals – can we ever defeat the persisters?

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Frank and Katherine May Lecture Theatre

Henry Wellcome Building

University of Leicester

Leicester

LE1 7RH

United Kingdom

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Event description
Inaugural lecture focusing on the current research into strategies for detection and elimination of persisting pathogens

About this Event

Join us on Tuesday 16 June as Professor Galina Mukamolova gives her inaugural lecture entitled:

Fighting immortals – can we ever defeat persisters?

The lecture will be held at 5.30pm in the Frank and Katherine May Lecture Theatre, HWB.

Join us afterwards for drinks and nibbles.

For more information please contact Dr Danni Benyon-Payne - dmrbp1@le.ac.uk

Synopsis

Bacteria can withstand the pressures of immune system and antibiotic treatment by adopting a dormant state. Dormant bacteria are often called persisters, because they are more difficult to treat and eliminate from infected individuals. Dormant pathogens have been long associated with latent infections and failed treatments. The lecture will be focused on recent insights into the biology of persister cells with the main emphasis on Mycobacterium tuberculosis, a well-known example of persister-producing pathogens. Molecular mechanisms underlying dormancy and resuscitation of dormant bacteria will be reviewed. The lecture will be completed with a discussion of novel strategies for detection and elimination of persisting pathogens.

Biography

Professor Mukamolova obtained her Doctoral degree at the Bach Institute of Biochemistry, Russian Academy of Sciences, where she studied dormancy of non-pathogenic microorganisms. During her PhD she started exploring means for resuscitation of dormant bacteria by co-discovering and characterising so-called Resuscitation-promoting factors (Rpf), a family of secreted enzymes with cell wall remodelling activity, in collaboration with the University of Aberystwyth. She moved to Aberystwyth where she continued her work on Rpf in mycobacteria as a post-doctoral associate. To obtain training and expertise in growing and handling Mycobacterium tuberculosis she went to the University of Texas Health Centre at Tyler. In 2007 Professor Mukamolova joined the Department of Infection, Immunity and Inflammation at the University of Leicester as a Wellcome Trust Value-in-People Award fellow. She has been working at the University of Leicester for the last 13 years mainly on tuberculosis. The central theme of Professor Mukamolova’s work is elucidation of molecular mechanisms which mediate transition to dormancy and resuscitation from dormancy. Her current research interests include characterisation of dormant persisters recovered from infected humans and animals, development of models for testing novel drugs targeting persisters and understanding signalling mechanisms that control bacterial division and cell wall biosynthesis.

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Frank and Katherine May Lecture Theatre

Henry Wellcome Building

University of Leicester

Leicester

LE1 7RH

United Kingdom

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