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GENiE Workshop - C.elegans consensus metabolic reconstruction

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The Babraham Institute

Babraham Research Campus

Babraham

CB22 3AT

United Kingdom

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Of the five attributes that define life - motility, growth, excitability, reproduction and metabolism - metabolism is the most essential since it supplies the energy and substances needed for all the others. Although studied for centuries, our knowledge of metabolism is still incomplete. A premier model organism for the study of metabolism is the small roundworm Caenorhabditis elegans, which facilitates studying the relationship between nutrition, gene expression, metabolism and phenotypic traits.

Recently, the first two reconstructions of C. elegans metabolism were published. These reconstructions contain whole-genome maps of interrelated reactions and metabolites, serving as blueprints of C. elegans metabolism and laying the foundation for further research. The first reconstruction, iCEL1273, contains 1985 metabolic reactions and 887 compounds, while the other reconstruction, ElegCyc, contains 1914 reactions and 1640 compounds. It is not yet clear to which extent the two reconstructions overlap. Parallel to these two published versions, other groups have been working on their own reconstructions.

The objective of this workshop is to determine the current state in C. elegans metabolism research and how different metabolic reconstructions, published and nonpublished, can be integrated in a community-driven effort leading to a comprehensive consensus C. elegans metabolic reconstruction. Within the workshop, researchers from both 'wet-lab' and 'dry-lab' contexts will exchange knowledge and experiences, sharing insights into how different types of data can be integrated using metabolic reconstructions.

This workshop is for researchers with an interest in C. elegans metabolomics and is not suitable for a public audience. The full programme for the event can be found here.

Abstract submissions are welcomed for short talks (15 minutes) for the first day of the workshop. Please submit you abstract either during registration or to janna.hastings@babraham.ac.uk by Friday 31st March.

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The Babraham Institute

Babraham Research Campus

Babraham

CB22 3AT

United Kingdom

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