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Inaugural Lecture: Professor Frank Dudbridge

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The Frank and Katherine May Lecture Theatre

Henry Wellcome Building

University of Leicester

Leicester

LE1 7RH

United Kingdom

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On Thursday 3 May 2018, Professor Frank Dudbridge (department of Health Sciences) will give his inaugural lecture entitled: 'Polygenic Epidemiology: the whole genome as a risk factor for disease'.

Synopsis

One hundred years since Fisher proposed a polygenic model for complex traits, genome-wide association studies have confirmed that all common diseases are influenced by thousands of genetic variants with small effects. Current studies have discovered only a small fraction of these variants. But by treating the whole genome as a risk factor, the polygenic basis of disease can be used in epidemiological studies without identifying all the individual risk variants. I will review the emergence of this new field of polygenic epidemiology, discuss current applications including diagnosis, risk prediction and causal inference, and identify some challenges that lie ahead.

Biography

Frank Dudbridge obtained his BSc in Mathematics and Computing from King’s College London and his PhD from Imperial College London on the subject of fractal image compression. After a postdoctoral fellowship at the University of California, San Diego he returned to the UK and discovered statistical genetics under John Todd at the Universities of Oxford and Cambridge. Following an MRC training fellowship he was a senior statistician at the MRC Biostatistics Unit, then Reader and Professor of Statistical Genetics at the London School of Hygiene and Tropical Medicine before joining the University of Leicester in 2016.

His interests are in statistical methods for genetic epidemiology, in which he has made highly cited contributions to family-based association analysis, genome-wide association studies, genetic risk prediction and Mendelian randomisation. These are the fruits of collaborations with many outstanding colleagues in fields including cardiology, oncology, psychiatry and diabetes.

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The Frank and Katherine May Lecture Theatre

Henry Wellcome Building

University of Leicester

Leicester

LE1 7RH

United Kingdom

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