Innovation Forum Okinawa Seminar Series - Ginkgo Bioworks

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Okinawa Institute of Science and Technology Graduate University

Seminar Room C209

Onna-son, Okinawa-ken 904-0412

Japan

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Ginkgo Bioworks was founded in 2009 by 4 MIT graduate students and their PI. The company aims to bring industrial efficiency to biology by designing and engineering microorganisms as production factories of useful ingredients for perfumes, foods, cosmetics, enzymes, and more. In the last 10 years, the company has raised more than $400M from investors, including Bill Gates, and has partnered with leading companies worldwide, such as Ajinomoto, Bayer, and Genomatica.

In this Innovation Forum Okinawa Seminar Series talk, Ginkgo Bioworks Associate Head of Metabolic Engineering, Dr. Massimo Merighi, will discuss the founding of the company and its strategy. He will also cover the history of rational and unbiased approaches to biological engineering and compare it to those being pursued by Ginkgo Bioworks.

Talk 1: 11.00 - 12.00

"Ginkgo Bioworks and the challenges of making biology easier to engineer"

Massimo Merighi, Ginkgo Bioworks, USA

Abstract:
Biological engineering history in the context of rational and unbiased approaches will be discussed and compared contrasted with Ginkgo approach to organism engineering.


Talk 2: 16.00 - 17.00

"Rapid pathway prototyping for novel bio-based chemicals: Ginkgo case studies"

Massimo Merighi, Ginkgo Bioworks, USA

Abstract:

Rapid prototyping of novel metabolic pathways for bio-based chemicals is often a requirement for proof of concept, appropriate project derisking, and ultimately for more accurate program costing. The process requirements are to explore an as granular and possible metabolic space, both in term of enzyme diversity and expression levels, in a short period of time, and containing cost. The Ginkgo Bioworks foundry, combining highly automated synthetic biology unit operations with high-throughput analytics controlled by custom scheduling software, is ideally suited for massively parallel approaches that can significantly reduce the time required for pathway prototyping.

We will discuss several case studies of pathways developed by Ginkgo, in particular one involving the engineering of a substrate co-feed in Escherichia coli, and the second concerning the engineering for the production of a platform chemical intermediate, also in E.coli. We will present data outlining the essence of our design cycle, its trade-offs in term of cost and benefit and timelines, including a history of how this design cycle has evolved over time to take advantage of new technological developments.


Date and Time

Location

Okinawa Institute of Science and Technology Graduate University

Seminar Room C209

Onna-son, Okinawa-ken 904-0412

Japan

View Map

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