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MAPP Lecture Series - Dr Ifty Ahmed

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University of Sheffield

Sir Robert Hadfield Building, LT22

Mappin Street

Sheffield

S1 3JD

United Kingdom

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'Manufacturing Micro Spherical and Porous Particles from Glasses and Glass Ceramics'

Abstract

Silicates and more recently Borate-based glasses have achieved great success for use in biomedical applications. However, Phosphate-based glasses have also been widely explored and offer greater versatility as their degradation profiles can be fully controlled. As the principal chemical constituent of bone mineral is calcium phosphate, these glasses are ideal candidates as they mainly contain P2O5, CaO and Na2O (and can easily incorporate many other oxides). Increasing or decreasing the oxide components or incorporating others enables further control over their dissolution rates (which can range from a day/s, week/s, months to years). We have recently developed solid (non-porous) and highly porous microspheres from the above mentioned glass materials (including glass-ceramic, namely apatite wollastonite), via a single-stage manufacturing process. The lab-scale process developed can also deliver yields of between 1-2 kg per hour. The porous microspheres developed from phosphate-based glasses are being explored for orthobiologic applications via stem cell incorporation, with a view to develop a prophylactic fracture prevention treatment option for elderly osteoporosis patients. The porous microsphere manufacturing process has also been applied to other materials, which are being explored for alternate applications (such as water treatment). As such, the manufacturing process is considered to be a potential platform technology.

The lecture will begin at 12noon and will be followed by lunch in the Turner Museum at 1pm.

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University of Sheffield

Sir Robert Hadfield Building, LT22

Mappin Street

Sheffield

S1 3JD

United Kingdom

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