Confirmed speakers include Professor David Price, UCL Vice-Provost (Research, Innovation & Global Engagement), Professor David Lomas, Vice Provost (Health), Professor of Virology, UCL Judith Breuer, David Probert Chief Executive at UCLH & Professor Stephen H Powis, National Medical Director of NHS England and Professor of Renal Medicine at University College London.

Professor Steve Myint will be chairing the panel discussions.

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When: Jan 26, 2022 09:00 AM London

Topic: Precision AMR Conference 26th Jan 2022

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Agenda for Session 1 (9:00 – 11:00am)

9:00 to 9:10 Welcome & Summary of Achievements of Precision AMR ,Prof Judy Breuer, Professor of Virology, UCL GOS Institute of Child Health, PI of Precision AMR.

9:10 to 9:35 Where does AMR fit in UCL’s Research Agenda , Prof David Price, UCL Vice-Provost (Research, Innovation & Global Engagement).

9:35 to 9:45 Gut Microbiota, Antibiotic Therapy & Antimicrobial Resistance, Prof Mona Bajaj-Elliott, Dr Damien Richard & Dr John Readman, Infection, Immunity & Inflammation Dept, UCL GOS Institute of Child Health.

9:50 to 10:00 BRC Priorities and Strategy in AMR and Infection Research, Prof Mahdad Noursadeghi, Professor of Infectious Diseases, Division of Infection & Immunity, UCL.

10:00 to 10:10 Reconstructing the spread of bacterial mobile elements Prof Francois Balloux, UCL Genetics Institute / UCL Department of Genetics, Evolution & Environment.

10:10 to 11:00 Panel Discussion with:

• Dr Gemma Buckland-Merrett (Research Lead, Drug-Resistant Infections Infectious Diseases at Wellcome Trust);

• Prof Geraint Rees, UCL Pro-Provost (Academic Planning), UCL Pro-Vice-Provost (Artificial Intelligence) and a Professor of Cognitive Neurology at University College London;

• Prof Pia Hardelid, Population, Policy & Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, Associate Professor of Epidemiology;

• Prof Matthew Todd, Professor and Chair of Drug Discovery of the School of Pharmacy at University College London and founder of Open Source drug discovery initiatives;

• Prof Richard Stratton, Consultant and Senior Lecturer at the Centre for Rheumatology, within the division of medicine at UCL and Clinical Lead for Rheumatology at the Royal Free London NHS;

• Prof Judy Breuer, Professor of Virology and Principal Investigator of Precision AMR at UCH GOS ICH; • Chaired by Prof Steven Myint, currently Chair of CCRL, Co-Chairman the Royal College of Surgeons of England and Entrepreneur in Residence at the National University of Singapore.

11:00 to 11:30 Mid-morning Break – 4 Conversations about AMR - clips and extracts of panels from Rise of the Resistance (30 minutes)

11:30 to 11:40 Antibody Therapy for Acinetobacter baumannii Infections, Prof Jeremy Brown, Professor of Respiratory Infection, Respiratory Medicine, Division of Medicine, UCL.

11:40 to 11:50 Medicine Discovery Catapult: Delivering AMR projects through partnership, Dr Helen Bright, Medicine Catapult

11:50 to 12:00 Data-driven approaches to reduce inappropriate antibiotic prescribing in hospital, Prof Laura Shallcross, Professor of Public Health & Translational Data Science, Institute of Health Informatics, UCL

12:00 to 12:30 Rise of The Resistance, Raising Awareness of AMR, Dr Elaine Cloutman-Green, Great Ormond Street Hospital, Sue Lee & Nicola Baldwin, Visiting Research Fellow, Institute of Advanced Studies, UCL (introduce video over lunch)

12:30 to 13:30 LUNCH Video '9 Short Films on AMR' - compilation of short artist / collaboration films from Rise of the Resistance (60 minutes)

13:30 to 13:55 The importance of AMR at UCLH, David Probert, UCLH, Chief Executive

13:55 to 14:15 Developing a Novel Antibiotic – Early Stages, Prof Christopher O’Callaghan, Professor of Respiratory & Paediatric Medicine, UCL Great Ormond Street Institute of Child Health

14:15 to 14:30 Quorum Sensing? PPI Communication and Behaviour, Dr Elaine Cloutman-Green, Sue Lee & Nicola Baldwin, Visiting Research Fellow, Institute of Advanced Studies, UCL

14:30 to 15:20 Afternoon Coffee & Tea Break

Video 9 Short Theses on AMR' - compilation of Precision AMR researchers giving short presentations on their projects (30 minutes)

15:20 to 15:40 Strategic Direction of AMR within Division of Health at UCL, Prof David Lomas, Vice Provost (Health) at UCL, Head of the School of Life and Medical Sciences and Head of UCL Medical School.

15:40 to 16:00 Prof Stephen H Powis, National Medical Director of NHS England and Professor of Renal Medicine at University College London.

16:00 to 16:50 Panel Discussion

• Prof David Lomas, Vice Provost (Health) at UCL, Head of the School of Life and Medical Sciences and Head of UCL Medical School.

• Prof Stephen H Powis, National Medical Director of NHS England and Professor of Renal Medicine at University College London.

• Prof Robert Heyderman, Head of Research Department of Infection and Professor of Infectious Diseases and International Health at UCL.

• Prof Ivan Parkin, Faculty Dean of Mathematical & Physical Sciences and Professor of Inorganic Materials Chemistry at UCL.

• David Probert, Current Chief Executive of UCLH. Previously Chief Executive of Moorfields Eye Hospital NHS Foundation Trust since April 2016.

• Prof Emma Morris, Director of UCL Division of Infection and Immunity and Professor of Clinical Cell and Gene Therapy.

• Prof Judy Breuer, Professor of Virology and Principal Investigator of Precision AMR at UCH GOS ICH.

• Chaired by Prof Steven Myint, currently Chair of CCRL, Co-Chairman the Royal College of Surgeons of England and Entrepreneur in Residence at the National University of Singapore.

16:50 to 17:00 Final Thoughts & Future Directions Judy Breuer

17:00 to 17:30 `What Is AMR And What Can We Do About It?' video of hybrid performance / science presentation by actors and scientists recorded at Bloomsbury Theatre Studio.

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Rise of the Resistance: Precision AMR PPI and Public Engagement

Precision AMR PPI was coordinated by playwright Nicola Baldwin, Visiting Creative Fellow at UCL IAS, in partnership with the Nosocomial Project, a theatre and events collaborative of Healthcare Scientists and artists set-up by Nicola Baldwin and Dr Elaine Cloutman-Green, Lead Clinical Scientist at GOSH. Sue Lee was lay advisor. Activities included workshops, a ‘mini-thesis’ challenge for Precision AMR researchers, artist commissions and events, and two public festivals: Rise of the Resistance 1 (online) in June; Rise of the Resistance 2, live and livestreamed at Bloomsbury Theatre in September to commemorate the discovery of penicillin.

We are pleased to present the following PPI films.

Film 1 - RISE OF THE RESISTANCE: 4 conversations on AMR

Compilation of extracts from films & panel discussions, Rise of the Resistance 1

Watch now https://youtu.be/wDuMIOIgB0c

Spiralling written, spoken and directed Jimena Larraguivel

Photography Flora Westbrook; Sound engineer and editor Victor Rios

Panel 1: How To Begin the AMR Conversation

With Dr Melisa Canales, Professor Brendan Gilmore, Dr James Hatcher, Sue Lee

Into The Breach written, performed and directed by David Milner

Edited by Louis Milner; Music “Proud” by Lol K (Halcyon Veil)

Panel 2: Bugs and Behaviour

With Dr Jane Freeman, Angela Mwape, Ruth Thomsen, Francis Yongblah

NOSOCOMIAL written and directed by Nicola Baldwin

Editor Becky Simon; Composer / music and editor Louis Milner. Production assistant Rose Dolan

Actors: Jimena Larraguivel, Becky Simon, Nicola Sanderson, Peter Clements

Scientists: Victoria Heath, Anthony De Souza, Francis Yongblah, Dr Elaine Cloutman-Green

Panel 3: The Value of Collaboration

With Dr Lena Ciric, Monika Gravagno, Saskia Marland

ME AND HER created and performed by Rebecca Simon

Panel 4: Human and Animal Impact of AMR

With Dr Elaine Cloutman-Green, Professor Mark Fielder, Professor Nicola Williams

All films and panels produced by NOSOCOMIAL for Rise Of The Resistance Festival

Film 2 - RISE OF THE RESISTANCE: 9 short films on AMR

Compilation of extracts and short films in response to AMR, from Rise of the Resistance 1 & 2.

Watch now https://youtu.be/M2G8NpWpLBA

Spiralling written, spoken, and directed by Jimena Larraguivel

Photography Flora Westbrook; Sound engineer and editor Victor Rios

in a time where views are drastically polarised, aren’t questions what could potentially bring us together and not further apart?

Into The Breach written, performed, and directed by David Milner

Edited by Louis Milner; Music “Proud” by Lol K (Halcyon Veil)

Hostel dweller COLIN is in limbo, awaiting an operation; his body must be drug-free for surgery, but addiction has been the one constant in his life.

ME AND HER created and performed by Rebecca Simon

A family struggling with their child’s long term hospital stay. What’s the prognosis for their careers, relationships and sense of identity?

NOSOCOMIAL written and directed by Nicola Baldwin

Editor Becky Simon; Composer / music & editor Louis Milner. Production assistant Rose Dolan

Actors: Jimena Larraguivel, Becky Simon, Nicola Sanderson, Peter Clements

Scientists: Victoria Heath, Anthony De Souza, Francis Yongblah, Dr Elaine Cloutman-Green

Hospital scientists battle a mystery illness. Adapted from the award-winning play based on the verbatim stories of NHS Healthcare Scientists.

Klebsiella written and performed by Peter Clements

Filmed by Rebecca Simon; frock by Pam Tait; Science by Dr Elaine Cloutman-Green

Klebsiella, shapeshifter of the microbial world – who is she? Why does she do these things? In a crisis of identity, Klebsiella seeks psychotherapy to get to the bottom of what’s bugging her.

La Biotique conceived and written by Rahila Gupta

Adapted & directed by Nicola Baldwin; camera Nicola Baldwin; edit Louis Milner

MIMI Radhika Aggarwal. Singer Otis-Cameron Carr

Contemporary reworking of aria from Puccini’s opera La Boheme. Mimi, a migrant textile worker in today's London, sings of her heartbreak as she contemplates death from TB.

Sock The Puppet written by Nicola Baldwin in collaboration with Dr Elaine Cloutman-Green

Directed by Saskia Marland; filmed and edited by Rebecca Simon; puppet maker Abi Bown

Performed by Stephanie Houtman

A puppet story for kids about Socks, Science, Superbugs, and making friends.

Make A Friend For Sock created and performed by Abi Bown

Edited by Rebecca Simon. With thanks to Cody Dock.

Designer and Maker Abi shows you how to make a new friend for Sock the Puppet.

Humans, Animals and Microbes Professor Mark Fielder and Dr Elaine Cloutman-Green

Filmed and edited by Rebecca Simon. A visit to UCL Grant Museum of Zoology with Professor Mark Fielder and Dr Elaine Cloutman-Green, discussing microbes, AMR and One Health.

Produced by Nosocomial for Rise of the Resistance

Film 3 - RISE OF THE RESISTANCE: 9 short theses by Precision AMR researchers

Compilation of short films and ‘3 Minute Thesis’ PPI presentations by Precision AMR researchers.

Watch now https://youtu.be/UCp3f3Omblw

Antimicrobial Resistance and kidney transplantation, Dr Jennifer Rohn, UCL Division of Medicine

Killing bacteria with your jewellery? Gold Nanoparticles as Stable Anti-microbial Surfaces, Nidhi Kapil, UCL Department of Chemical Engineering

Save Our Drugs; Combination Therapy in AMR Stewardship, Dimitrios Evangelopoulos, UCL Eastman Dental Institute

How Clean Is Your Water? Jack Lee, Department of Microbiology, Great Ormond Street Hospital

Hollow-Fibre Model of Mycobacterium abscessus disease to test new antibiotics, Dr Stephen Morris-Jones, University College London Hospitals

Pee: using machine learning to predict bacteriuria, Patrick Rockenschaub, UCL Institute of Health Informatics

Alert! Rise of the Superbugs! Nicole Rudi, UCL Great Ormond Street Institute of Child Health

Do you really need those antibiotics? Dr Steven Kemp, Jeffrey Cheah Biomedical Centre, Cambridge

Inhale Poem, Amanda Wellings and Dr Vivre Enne, UCL Division of Infection & Immunity

All films produced by Precision AMR seed funded researchers for Rise of the Resistance.

Film 4 - RISE OF THE RESISTANCE: What Is AMR And What Can We Do About It?

Performance by actors, writers and Precision AMR scientists recorded live at Bloomsbury Theatre. Rise of the Resistance festival launch event, September 2021.

Watch now https://youtu.be/ME2eCZNK3yI

On 3 September 2021, Rise of the Resistance celebrated the 93rd birthday of antibiotics with a theatrical conversation between Healthcare Scientists, Precision AMR researchers, artists, and patients on the looming health crisis of antimicrobial resistance (AMR). What can we learn from microbes about innovation and cooperation? What can we learn from each other by sharing expertise and experience? What is AMR and what can we do about it?

Performed by: Nidhi Kapil, Tara Kearney, Dr Steven Kemp, Nicola Sanderson, Helen Sheals, Rebecca Simon, Sam Watkin, Jonny Wright, Özge Yetiş

With speeches from: Mrs X by Nicola Baldwin; Nobel Prize ceremony 1945 by Dr Alexander Fleming; Killing bacteria with your jewellery? by Nidhi Kapil; Do you really need those antibiotics? by Dr Steven Kemp; Lucky Jen by Nicola Sanderson; Me And Her by Rebecca Simon; My Motivations by Sam Watkin; P. aeruginosa in hospital showers by Özge Yetiş

Additional text:

Dr Elaine Cloutman-Green, Anthony de Souza, Halan Mohamed, Sue Lee, Dr Jennifer Rohn

Devised and directed by Nicola Baldwin

Filmed at Bloomsbury Theatre Studio by Theatrical Solutions. Edited by Louis Milner

PPI Credits

PPI Coordinator Nicola Baldwin

Healthcare Science coordinator Dr Elaine Cloutman-Green

Lay advisor Sue Lee

Nosocomial Rebecca Simon, Louis Milner

Production assistant Rose Dolan

Livestreaming Theatrical Solutions

Precision AMR Charlene Murphy, Saadia Rahman

https://www.nosocomial.online/

@NosocomialThe

https://www.ucl.ac.uk/infection-immunity/people/professor-judith-breuer/precision-amr

@AmrPrecision