Free

Physiology and Pathophysiology in Synapse

Event Information

Share this event

Date and Time

Location

Location

Safra Lecture Theatre, King's Venues

Strand

London

WC2R 2LS

United Kingdom

View Map

Event description

Description

Physiology and Pathophysiology in Synapse

Progressive synapse dysfunction in the brain results in cognitive impairment. The precise mechanism(s) responsible for the declining memory function in diseases such as Alzheimer’s diseases is not completely understood. Growing evidence indicates that functional weakening and a reduction of synapse size correlate with severity of neurodegenerative diseases. However, despite the use of various experimental models and numerous studies, we have yet to fully define the core biology associated with this pathophysiology.

This symposium will provide an outstanding international forum for synapse biology in physiological and pathophysiological conditions, allowing for stimulating discussions and the exchange of new ideas to challenge therapeutic intervention.


This symposium is organised by UK DRI at King's College London, Scientifica and Coherent

red kings college london logo with white letters

uk dementia research institute logo

Scientifica logo

coherent logo black letters on white background



27 June 2019

Safra Lecture Theatre

King's Building

King’s College London

Strand, London WC2R 2LS

09:00 Registration

09:20 Opening Remarks, Kei Cho (DRI at King’s College London)

09:25 Haruhiko Bito (Tokyo Univ., Japan) – Arc-haeology of long-term memory

10:00 Albert Lee (Janelia, USA) – The statistical structure of hippocampal representations

10:25 Matt Jones (Bristol) – Psychiatric risk synapses and their thalamic-cortical-limbic consequences

10:50 Coffee Break

11:10 Sam Cooke (King’s College London) – Cortical synaptic plasticity arising from experience and deprivation

11:35 Sam Barnes (DRI at Imperial College) – Functional signatures of homeostatic plasticity in vivo

12:00 Scientifica & Coherent Using FLIM in synaptic physiology

12:20 Break

13:30 Anne Bertolotti (LMB-Cambridge) - Inhibition of eIF2a phosphatases as a possible treatment for neurodegenerative diseases

13:55 David Klenerman (DRI at Cambridge) – Studying single aggregates to determine the molecular basis of Alzheimer’s disease

14:20 Michisuke Yuzaki (Keio Univ., Japan) – How to make and destroy synapses: New tools to modify function and structure

14:45 Coffee Break

15:05 Zheng Li (NIH, USA) – Crosstalk of caspases and autophagy in synaptic plasticity

15:30 Kei Cho (DRI at King’s College London) - Weakening of postsynaptic M1 muscarinic acetylcholine receptor in Alzheimer’s disease

15:55 Marco Brancaccio (DRI at Imperial College London) – Astrocytic-neuronal interplay in the generation of circadian rhythms

16:20 Chis Shaw (DRI at King’s College London) - Closing Remarks

28 June 2019

2 photon microscopy, hands on session- Scientifica & Coherent

To request a place, please contact Chloe Emmerson at chloe.emmerson@scientifica.uk.com

(Limited spaces available)

Share with friends

Date and Time

Location

Safra Lecture Theatre, King's Venues

Strand

London

WC2R 2LS

United Kingdom

View Map

Save This Event

Event Saved