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The economics of precision medicine: Accounting for imperfect uptake and as...

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Room 9.58 (b), 9th Floor, Worsley Building, The University of Leeds

Clarendon Way

Leeds

LS2 9NL

United Kingdom

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Background: Although the potential benefits of precision medicine (PM) are substantial, to date the adoption of PM technologies has been slow. A robust evidence base for clinical effectiveness is essential but not sufficient condition for clinical adoption. Key barriers to successful adoption include: 1) stakeholder awareness and education, 2) patient empowerment, 3) value recognition across multiple stakeholders, 4) infrastructure, data and information management and 5) access to care[1].

The majority of economic evaluations assume perfect uptake of novel precision medicine strategies[2]. This assumption is rarely valid and overlooks a potentially costly component of investment decisions: the cost of implementation. Furthermore, the cost of the implementation falls across an array of stakeholders. Whilst methodologies to evaluate the cost-effectiveness of investing in implementation strategies have been published[3][4], their pertinence to the evaluation of precision medicine strategies is yet to be fully explored.

In this participatory one day workshop, sponsored by Genome Canada, Institute for Health Economics, Alberta Innovates, NIHR Leeds Diagnostic Evidence Cooperative and the Leeds Centre for Personalised Medicine and Health, we will discuss implementation challenges to the adoption of PM technologies and how they may be surmountable. The output from the workshop will identify collaborative research opportunities to apply and build upon existing approaches to evaluating the value of implementation strategies reflecting the specific characteristics of PM technologies.



[1] Pritchard et al. (2017) Strategies for integrating personalized medicine into healthcare practice. Personalized Medicine, 14(2); 141-152.

[2] Shabaruddin et al. (2015) Economic evaluations of personalized medicine: existing challenges and current developments. Pharmgenomics Pers Med, 24(8); 115-26.

[3] Fenwick et al. (2008) The value of implementation and the value of information: combined and uneven development. Medical Decision Making 28(1): 21-32.

[4] Walker et al. (2013) Getting cost-effectiveness technologies into practice: the value of implementation. EEPRU Research Report No.14,www.eepru.org.uk/Getting%20cost-effectiveness%20-%20014.pdf.

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Room 9.58 (b), 9th Floor, Worsley Building, The University of Leeds

Clarendon Way

Leeds

LS2 9NL

United Kingdom

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