About the lecture – ‘Reading your DNA’

DNA is a linear molecule that comprises four building blocks, often abbreviated to the letters G, C, T and A. The sequence of these four letters constitutes a code that comprises 3.2 billion letters in a copy of the human genome. The International Human Genome Project used an approach developed by Fred Sanger to generate the first human genome reference in a global collaboration that spanned a decade. Over 20 years ago, during the course of some basic scientific experiments, a collaboration with David Klenerman and our co-workers, unexpectedly led us to conceive and then pursue a different way of sequencing DNA. The initial experiments ultimately led to a rapid, low-cost sequencing approach, which was developed and commercialised through a company we co-founded, called Solexa. Today the technique is able to sequence human, and other, genomes at a cost and speed that shows over a million-fold improvement compared to when we began the project in 1997. I will also discuss some of our more recent work on the chemistry, sequencing and function of DNA epigenetics.

About the speaker

Sir Shankar Balasubramanian is the Herchel Smith Professor of Medicinal Chemistry at the University of Cambridge and senior group leader at Cancer Research UK’s Cambridge Institute. He works on the chemistry, structure and function of nucleic acids.

He is a co-inventor (with Sir David Klenerman) of the leading next generation DNA sequencing methodology, Solexa sequencing (now Illumina) that has made routine, accurate, low-cost sequencing of human genomes a reality and has revolutionised biology. He has invented chemistry to decode several modified (epigenetic) DNA bases and DNA secondary structures (G-quadruplexes) in the genome and has made seminal contributions towards the understanding of their dynamics and function. His work on small molecule recognition of nucleic acids has revealed molecular mechanisms that can be exploited to modulate the biology of cancer. His collective contributions span fundamental chemistry and its application to the biological and medical sciences.

Sir Shankar was knighted in the Queen’s New Year’s Honours in 2017 for his services to science and medicine and awarded the Royal Society’s Royal Medal in 2018. In 2021, he was awarded the 2020 Millennium Technology Prize jointly with Sir David Klenerman and the 2022 Breakthrough Prize for Life Sciences jointly with Sir David Klenerman and Pascal Mayer for their work on sequencing technologies. In 2023, he was elected as an international member of the National Academy of Sciences and in 2024 he was awarded the Novo Nordisk Award with Sir David Klenerman and the Gairdner Prize in Life Sciences jointly with Sir David Klenerman and Pascal Mayer.

Please book your in-person tickets via this page.

Alternatively, Zoom spaces can be reserved at: https://www.eventbrite.co.uk/e/the-king-lecture-202425-sir-shankar-balasubramanian-zoom-tickets-1117906240659?aff=oddtdtcreator

Note: This event will be held in the Robinson College Auditorium, Grange Rd, Cambridge CB3 9AN

The King Lecture 2024/25 - Sir Shankar Balasubramanian (In-person)