Programme

Theme: “DIAGNOSTIC AND THERAPEUTIC CARDIOVASCULAR GENOMICS”

Day 1 Thursday 16th September 2021

Registration 1200-1300 (BST/UK)

1215 Welcome/ Introduction

Professor Dhavendra Kumar, Chair Organising/ Scientific Committees

1230- 1330 Session I: Genomics in Cardiovascular Science

Chair Professor Patricia Munroe, PhD, FMedSci

Inherited Cardiac Disorders: Beyond Mendelian Inheritance

Dr. Connie Bezzina, Academic Medical Centre, University Amsterdam, NL

Genetic architecture of inherited cardiac conditions- insights from recent genomic advances

Dr. James Ware, Cardiovascular Genomic Medicine, Imperial/ Brompton, London, UK

Cardiovascular metabolomics

Sandosh Padmanabhan, Department of Cardiovascular Science, University of Glasgow, Scotland.

1330-1430 Plenary 1

Chair Professor Panos Deloukas, PhD, FMedSci

‘Mainstreaming genomic medicine across the NHS’

Professor Dame Sue Hill,

Chief Scientific Officer for England and Senior Responsible Officer for Genomics in NHS England and NHS Improvement

1430-1500 Comfort break

1500-1700 Session II: Genomics of cardiovascular development

Chair (s) Professor Ruth Newbury-Ecob, Bristol

Clinical genome sequencing in congenital cardiology

Professor Graham Stuart, Bristol, UK

New genes for congenital cardiac anomaly conditions

Dr. Anna Wisdon, Bristol, UK

1730-1830 Plenary 2 ‘Multi-disciplinary dimensions of genomic medicine’

Chair (s) Dr. Sarju Mehta, Clinical Genetics, Addenbrookes, Cambridge, UK

Genetic perspectives of inflammatory cardiomyopathy

Dr. Neha Sekhri, Inherited Cardiac Diseases Unit, Bart’s NHS Foundation, London

Genotype-Histopathology correlations in cardiovascular genomic medicine

Dr. Pilichou Kalliopi, Padua, Italy

1830 Reflections of the Day & Close

Day 2 Friday 17th September 2021

1230- 1330 Session IV: Cardiac conduction and rhythm disorders

Chair (s) Professor Sylvia Priori, Pavia, Italy

Deepening complexities of cardiac arrhythmias

Professor Arthur Wilde, Molecular Cardiology, Amsterdam UMC, NL

Channelopathies across India

Professor Nitish Naik, Cardiology Centre, AIIMS, New Delhi, India

1330-1430 Plenary 3: Genomic dimensions of cardiac electrophysiology

Chair (s) Dr. Alison Muir, Consultant Cardiologist, Queen’s Medical Centre, Belfast

Genomics of the cardiac conduction system

Dr. Bas J. Boukens, AMC University Amsterdam, NL

Autonomic cardiac electrophysiology

Professor Pier Lambiase, UCL/ Bart’s, London, UK

1430-1500 Comfort break

1500-1700 Session V: Genomics of Cardiac musculature

Chair Dr. Amanda Varnava, St George’s London

Expanding horizon of cardiomyopathy genomics

Professor Perry Elliott, UCL Cardiovascular Research Centre/ Bart’s Inherited Heart Centre

Genomic profiling of cardiomyopathies in India

Professor Ajay Bahl, Cardiology, PGIMER, Chandigarh, UT, India.

Dilated cardiomyopathy associated with BAG3 mutation

Dr. Vanya Vaidya, Dept. Cardiology, PGIMER, Chandigarh, India

1700-1815 Plenary 4: New horizons in cardiovascular genomic medicine

Chair: Dr. Yasmine Aquib, Molecular Scientist, Sir Magdi Yaquib Aswan Heart Hospital, Aswan, Egypt.

Clinical use of RNAs in genomic medicine

Professor Diana Baralle, Clinical Genetics, Princess Anne Hospital, Southampton

Proteomics of Dystrophin Cardiomyopathy

Dr. Federica Montanaro, The Dubowitz Neuromuscular Centre, GOSH, UCL, London, UK

1815 Reflections of the Day & Close

Day 3 Saturday 18th September 2021

1230- 1330 Plenary 5: Therapeutic cardiovascular genomics

Chair: Dr. Eleanor Wicks, Consultant Cardiologist, John Radcliffe Hospital, Oxford, UK

Precision medicine in dilated cardiomyopathy

Professor Diane Fatkin, Victor Chang Cardiac Research Institute, NSW, Australia

Novel therapeutic developments in hypertrophic cardiomyopathy

Dr. Caroline Ho, Bingham Women Hospital, Harvard Medical School, Boston, USA

1330-1500 Session VII: Cardiovascular connective tissue genomics

Chair: Prof. Pradeep Vasudevan, Consultant Clinical Genetics, Leicester, UK

Genetics of spontaneous coronary artery dissection

Dr. Eleni Giannoulatou, Victor Chang Cardiac Research Institute, NSW, Australia

Cardiovascular phenotypes in osteogenesis imperfecta

Dr. Bala Subramanian, Sheffield Children’s Hospital

Genotype driven aortic surgical interventions

Professor Nimesh Desai, University of Pennsylvania, Philadelphia, USA

1500 Comfort break

1515-1600 Plenary Session VIII

Chair: Dr. Neha Sekhri, Bart’s Inherited Cardiac Diseases Centre

“Cardiovascular Genomic Medicine- What’s new?”

Professor Seema Mital, Sick Kids, Univ. Toronto, Canada

1600-1700 “The Second William Harvey Oration”

Chairs: Professor Dhavendra Kumar & Professor Arthur Wilde

“A journey towards Genomic Medicine”

Professor Dan M. Roden, M.D.

Professor of Medicine, Pharmacology, and Biomedical Informatics

Senior Vice President for Personalized Medicine

Vanderbilt University Medical Center, Nashville, TN, USA

1715 Reflections of the Conference, Vote of Thanks

Professor Sir Munir Pirmohamed, Liverpool, UK

All enquiries to-

Chair Organising and Scientific Committees

Professor Dhavendra Kumar, Consultant Clinical Genetics/ Cardiovascular Genomics; Chair, CEO/Med Director, Genomic Medicine Foundation UK.

d.kumar@qmul.ac.uk & md@genomicmedicine.org

Event Manager: Nick Miles, Neon Events Ltd. nick@neon-events.co.uk