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UCL Institute of Neurology

33 Queen Square



United Kingdom

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2018 Annual Synaptopathies Symposium


33 Queen Square Lecture Theatre


Friday, September 14th, 2018

About the symposium

The symposium is funded by a Wellcome Trust Strategic Award entitled "Synaptopathies: genetics, biophysics and circuit mechanisms of paroxysmal neurological disorders".

Epilepsy, migraine and related paroxysmal neurological disorders affect over 15% of the population, and account for an enormous burden to the individual and to society. Progress in managing these diseases is slow, with many patients failing to respond to available medication. Understanding the mechanisms will be an essential step, not only towards improved diagnosis, but also towards the development of rational therapies.

*This event is open to principal investigators, postdoctoral researchers and PhD students. A limited number of places will be made available to MSc students.*

The Programme

8.25 Registration, coffee

9.00 Dimitri Kullmann (UCL): Introduction

(Chair: Michael Hanna)

9.05 Louis Ptacek (San Francisco): Episodic disorders—channelopathies and beyond

9.40 Angela Vincent (Oxford) Autoimmune synaptopathies

10.15 Henry Martin (UCL): Synaptic adaptation in a model of Episodic Ataxia type 1

10.30 Christine Dixon (UCL): Neurodevelopmental disorders caused by de novo mutations in AMPA receptors

10.45 Coffee break

(Chair: Stephanie Schorge)

11.15 Leon Lagnado (U Sussex) An amplitude code increases the efficiency of information transmission across a sensory synapse

11.50 Tara Keck (UCL): Synaptic Mechanisms of Cortical Plasticity

12.25 Peter Giese (KCL) The synaptic basis of hippocampal memory changes with age

13.00 Lunch & Posters

(Chair: Kirill Volynski)

14.00 James Rothman (Yale/UCL) Insights into mechanisms of neurotransmitter release from newly discovered synaptopathies

14.35 Giampietro Schiavo (UCL) Deficits in axonal transport in ALS and Charcot-Marie-Tooth disease models

15.10 Vincenzo Salpietro (UCL) Neurological disorders caused by mutations in synaptobrevin genes

15.25 Patrick Kratschmer (UCL) In vivo analysis of an epilepsy- and dyskinesia-linked channelopathy using Drosophila

15.40 Tea break

(Chair: Henry Houlden)

16.05 Alicia Hidalgo (U Birmingham) A novel mechanism of structural plasticity involving neurotrophins, kinase-less Trk and Toll receptors in Drosophila

16.40 Jason Rihel (UCL) Sleep and Epilepsy in Zebrafish Autism Models

17.15 Michael Owen (Cardiff) Schizophrenia, synaptopathy and the neurodevelopmental continuum

17.50 Reception

Supported by the Wellcome Trust through a Strategic Award on Synaptopathies

To attend please register through the UCL Eventbrite page, accessible via:

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UCL Institute of Neurology

33 Queen Square



United Kingdom

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