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Young Lungs: How can new research approaches help us cure childhood asthma?...

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Lecture theatre TBC

TBC, Imperial College London

London

SW7 2AZ

United Kingdom

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The lecture is free to attend and open to all, but registration is required in advance - book your seat via the registration button on this page.

A pre-lecture reception with tea, coffee and cakes will be held from 16:45, whilst a wine reception with canapés will follow the lecture at 18:30 (venues TBC).
The venue will be communicated to attendees by email when confirmed.

Abstract

Asthma is one of the most common causes for childhood admission to hospital; although our understanding of the underlying mechanisms that trigger asthma symptoms has developed markedly, treatments that prevent wheezing attacks, especially in young pre-school children and children with very severe disease remain largely ineffective. Children with severe wheezing attacks and asthma have a lifelong loss in the function of their lungs. However, at present we do not have therapies that can prevent the effect of childhood asthma on long term lung health

To tackle these issues research is now taking a more targeted approach, with studies focusing on factors that determine whether or not wheezing symptoms in pre-school children develop into asthma and also how we can optimise treatments for children with really severe disease to stop them from having repeated hospital admissions, improve their quality of life and ideally prevent long term lung damage. These approaches include monitoring airway inflammation and infection over time by taking sputum samples in addition to blood to look for underlying mechanisms causing the symptoms. Alongside this, international clinical trials in pre-school children are now being funded to support development of more specific treatments targeted to this age group.

In her inaugural lecture Professor Sejal Saglani will highlight the importance of studying asthma in the very young in order to effectively tackle this debilitating disease in children. She will give an insight into how her research uses a unique translational approach to ensure findings from animal models are confirmed in patient samples and verified in clinical trials with young patients. Professor Saglani will outline the pioneering work being carried out by her research group to uncover the mechanisms that drive the disease in children and their progress made towards preventing and treating asthma in the youngest patient groups.

Biography

Sejal Saglani is Professor of Paediatric Respiratory Medicine within the National Heart and Lung Institute at Imperial College London. She completed her undergraduate degree in medicine at the University of Leicester. Professor Saglani then undertook her clinical training in general paediatrics in the Thames Region. Further training at The Royal London Hospital, Great Ormond Street Hospital and The Royal Brompton Hospital allowed her to obtain her Certificate of Specialist Training in Respiratory Paediatrics.

Dr Saglani took time out of her clinical training to undertake her postgraduate research at the National Heart and Lung Institute and The Royal Brompton Hospital, funded by Asthma UK, and supervised by Professor Andrew Bush and Professor Peter Jeffery. She obtained her MD degree investigating the pathology of infant and preschool wheeze and received the NHLI Thesis prize for her research.

Subsequent to completing her clinical training, Dr Saglani obtained a British Lung Foundation Research Fellowship to develop a neonatal mouse model of allergic airways disease. The establishment of this model has allowed her to obtain a Wellcome Intermediate Clinical Fellowship. She has since obtained an MRC Young Investigator Award and most recently an NIHR Career Development Fellowship. She was awarded the European Respiratory Society Young Investigator Award for Paediatric research in 2009, and The Romain Pauwels Award for Excellence in Translational Respiratory Research in 2015.

Dr Saglani's research interests include the pathology of infant and preschool wheeze, mechanisms of onset of airway remodelling in severe preschool wheeze and disease modifying therapies for preschool wheeze and childhood severe asthma.


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Location

Lecture theatre TBC

TBC, Imperial College London

London

SW7 2AZ

United Kingdom

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