The One Health Research for Biological Threats (ORBITS) project is designed to bridge research, practice, and policy communities to address critical questions in an uncertain world. ORBITS is a global One Health initiative tackling biological threats at the intersection of human, animal, and environmental health. By bringing together expertise across science, policy, and security, ORBITS addresses the complex forces, conflict, climate change, and inequality, that shape disease risk in fragile and rapidly changing settings.