Advanced Microscopy Workshop

EM Analytical combines expertise from a broad array of scientific and technical fields to provide state-of-the-art analytical services. From single samples to in-depth investigations, our flexible approach means we can adapt to suit your requirements.We provide analytical services for both academic and commercial research and development projects, as well as independent quality control and failure analysis. Our services include electron microscopy, fluorescence microscopy, and chemical analysis.We are based at Alderley Park, the UK’s largest bioscience campus, located in the heart of Cheshire, just a few miles from Manchester Airport. Our unique links within this world-class community provide an unrivalled range of analytical services and equipment. No other facility in the UK can offer such a complete range of services under one roof.Our facility is also available on an open access basis for you to use directly. Experienced users and novice researchers are equally welcome, we will provide you with all support and training.Contact usto find out more.

EM Analytical

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Join us for a series of short research talks and live demonstrations of advanced microscopy. Talks will be given by several external speakers, including the Medicines Discovery Catapult, discussing the research made possible by cutting-edge imaging methods. There will also be plenty of opportunities to get hands-on with the microscopes themselves. This half-day event will showcase the research enabled by techniques such as:
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<LI><IMG STYLE="float: right; margin-left: 10px; margin-bottom: 5px;" TITLE="Poly(glycerol sebacate) nanoparticles for encapsulation of hydrophobic anti-cancer drugs." ALT="Poly(glycerol sebacate) nanoparticles for encapsulation of hydrophobic anti-cancer drugs." SRC="https://cdn.evbuc.com/eventlogos/265712864/polyglycerolsebacatenanoparticles.jpg" HEIGHT="150">
Laser-free confocal Create crisp 3D sectioned images of many specimens, large or small including model organisms, such as C.elegans and Zebrafish, fungus and plant specimens, cell cultures and tissue specimens with the capability of time lapse data capture for live cell imaging. These images allow researchers to gain information to help in numerous research areas, including cancer research, neuroscience and developmental biology. 
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<LI><IMG STYLE="float: right; margin-left: 10px; margin-bottom: 5px;" ALT="" SRC="https://cdn.evbuc.com/eventlogos/265712864/fig3stedyconabberiorinstrumentsmedium.jpg" HEIGHT="141" WIDTH="321">
STED super-resolution A completely new class of nanoscope with unprecedented resolution down to 20nm. STED technology is used in cancer research, neurobiology, and developmental biology to resolve structures that can not be seen with conventional confocal microscopy due to the diffraction-barrier. It has helped to describe the Actin/Spectrin organisation in neurons and the symmetry of the nuclear pore complex. 
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<IMG STYLE="float: right; margin-left: 10px; margin-bottom: 5px;" TITLE="Conjugated Polymer Nanoparticles: Extremely bright fluorophores for fluorescent imaging applications" ALT="Conjugated Polymer Nanoparticles: Extremely bright fluorophores for fluorescent imaging applications" SRC="https://cdn.evbuc.com/eventlogos/265712864/img4444fotor.jpg" WIDTH="321">Conjugated Polymer Nanoparticles: Extremely bright fluorophores for fluorescent imaging applications Conjugated Polymer Nanoparticles (CPNs) are novel fluorophores with increased sensitivity and performance for fluorescent imaging techniques. The CPNs are based on fluorescent polymers developed for the visual display industry and are extremely bright and very stable (resistant to photo-bleaching in storage or under laser excitation, pH 4-10, and temperatures up 120°C). The CPNs can be linked to antibodies or other targeting molecules and used to label tissues or cells in immunofluorescent studies or flow cytometry. Their intense brightness additionally allows them to be used in binding studies, increasing sensitivity in assays such as ELISAs, Western blots and dot blots. The CPNs also contain iron oxide, making particles magnetic, which can be used to isolate the nanoparticle and any material they have bound to, as well as in Magnetic Resonance Imaging (MRI) and multimodal imaging studies. 
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<IMG STYLE="float: right; margin-left: 10px; margin-bottom: 5px;" TITLE="HeLa cells infected with Chlamydia trachomatis grown on photo-etched glass coverslips and labeled with fluorescent tagged anti-elementary body antibody. Credit: NIAID" ALT="HeLa cells infected with Chlamydia trachomatis grown on photo-etched glass coverslips and labeled with fluorescent tagged anti-elementary body antibody. Credit: NIAID" SRC="https://cdn.evbuc.com/eventlogos/265712864/85113992482ae35d9ea6.jpg" WIDTH="321">Correlative light and electron microscopy Correlative light and electron microscopy (CLEM) is the combination of fluorescence microscopy with high-resolution electron microscopy. The combination of the labelling power of fluorescence imaging and the high resolution structural information provided by electron microscopy makes correlative microscopy the perfect tool for studying the complex relation between form and function in biology. 
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Fluorescence lifetime imaging 
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<LI><IMG STYLE="float: right; margin-bottom: 5px; margin-left: 10px;" TITLE="Microscopic insect on the petal of a flower imaged using scanning electron microscopy" ALT="Microscopic insect on the petal of a flower imaged using scanning electron microscopy" SRC="https://cdn.evbuc.com/eventlogos/265712864/bug.jpg" WIDTH="321">
Scanning and transmission electron microscopy Image almost any sample material in nanometer resolution, from tissue sections, cell cultures, nanoparticles and even micelles in solution. This invaluable data supports detailed histopathology, immunocytochemistry, oncology and molecular biology. Label-free mapping of chemical elements gives additional information on ultrastructure and feature identification.
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<H4>Agenda</H4>
<UL STYLE="line-spacing: 1.5em;">
<LI>13:00 - 13:10 Introductions </LI>
<LI>13:10 - 13:30 Electron microscopy </LI>
<LI>13:30 - 13:50 Laser-free confocal </LI>
<LI>13:50 - 14:10 STED super-resolution </LI>
<LI>14:10 - 15:00 Break for demos </LI>
<LI>15:00 - 15:20 Conjugated Polymer Nanoparticles: Extremely bright fluorophores for fluorescent imaging applications </LI>
<LI>15:20 - 15:40 Correlative light and electron microscopy </LI>
<LI>15:40 - 16:00 Cryo-electron microscopy for drug delivery </LI>
<LI>16:00 - 16:40 Break for demos </LI>
<LI>16:40 - 17:00 Medicines Discovery Catapult "Advanced Microscopy in Drug Discovery"</LI>
</UL>

Advanced Microscopy Workshop

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Advanced Microscopy Workshop

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