Multiscale brain modelling:  Prof Egidio D’Angelo and Dr Claudia Casellato

CAMERA at the University of Bath and Bristol + Bath Creative R+D

CAMERA Expert speaker series: Prof Egidio D’Angelo and Dr Claudia Casellato

Chancellor's Building 1.12

Prof Egidio D’Angelo and Dr Claudia Casellato: Human Brain ProjectMultiscale brain modelling:from neurons to virtual brains and robotic controllersAddressing the multiscale brain organization, which is fundamental for the brain’s dynamic repertoire, remains challenging. In principle, it should be possible to model neurons and synapses in detail and then connect them into large neuronal assemblies to explain the relationship between microscopic phenomena and large-scale brain functions. More difficult is to infer neuronal functions from ensemble measurements like those currently obtained with MRI, EEG, MEG or PET. Here, theories and strategies are considered for combining bottom-up models, generated from the principles of neuronal biophysics, with top-down models, based on network and ensemble representations, providing effective multiscale simulations in virtual brains and closed-loop controllers. All these models are data-driven and intersect tightly with large structural and functional datasets for construction and validation, providing insight on the mechanisms generating brain dynamics and unveiling hidden model parameters through optimization methods. These strategies are illustrated through examples taken from a long modelling story on the cerebellum, which is deeply implicated in motor and cognitive control, opening perspectives for robotics and neurology.

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Multiscale brain modelling: Prof Egidio D’Angelo and Dr Claudia Casellato

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Multiscale brain modelling: Prof Egidio D’Angelo and Dr Claudia Casellato

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