QBIOX Colloquium Trinity Term 2017
Event Information
Description
The third QBIOX Colloquium will take place on Friday 26th May (5th week) and feature talks from Irena Udalova (Kennedy Institute of Rheumatology, https://www.kennedy.ox.ac.uk/team/irina-udalova) and Roman Fischer (Target Discovery Institute, https://www.ndm.ox.ac.uk/principal-investigators/researcher/roman-fischer).
1400-1445 - Irena Udalova, "Technological breakthroughs in comprehensive survey of cell phenotypes – can the analytical tools catch up?".
1445-1530 - Roman Fischer, "The ultra-deep proteome - the dawn of the "Post-Proteomic Era".
1530-1630 - Networking and refreshments.
We hope to see you there. As ever, tickets are not necessary, but registering to attend will help us with numbers for catering.
Abstracts
Irena Udalova - Technological breakthroughs in comprehensive survey of cell phenotypes – can the analytical tools catch up?
The ability to study the transcriptome, proteome – and other aspects – of many individual cells represents one of the most important technical breakthroughs and tools in biology and medical science of the past few years. They are revolutionising study of biological systems and human disease, enabling for example: hypothesis-free identification of rare pathogenic (or protective) cell subsets in chronic diseases, routine monitoring of patient immune phenotypes and direct discovery of mole cular targets in rare cell populations. In parallel, new computational and analytical approaches are being intensively developed to analyse the vast data sets generated by these technologies. However, there is still a huge gap between our ability to generate the data, analyse their technical soundness and actually interpret them. The QBIOX network may provide for a unique opportunity to complement recent investments in Oxford technical capabilities in single-cell technologies with the development of revolutionary, visionary ways of interpreting the data that would help Oxford researchers to compete as leaders in this field.
Roman Fischer - The ultra-deep proteome - the dawn of the "Post-Proteomic Era"
Proteomics is seen as the next logical step after genomics to understand life processes at the molecular level. With increasing capabilities of modern mass spectrometers the deep proteome (>8000 proteins detected) has become widely accessible, only to be replaced recently by the "Ultra-deep proteome" with ~14000 proteins detected in a single cell line. Furthermore, new data search algorithms and sample preparation methods allow not only to achieve comprehensive sequence coverage for the majority of proteins, but also to detect protein variations and single amino acid polymorphisms in proteins, further linking genomic variation to protein phenotypes. The combination of genomic and proteomic information on individual (patient) level could mark the beginning of the "Post-Proteomic Era".
